Danazol: A treatment option for idiopathic thrombocytopenic purpura in hemodialysis patients

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Danazol in non-splenectomized patients with refractory idiopathic thrombocytopenic purpura.

Seven non-splenectomized patients with chronic refractory idiopathic thrombocytopenic purpura were treated with danazol 800 mg daily. All were glucocorticoid failures and four were refractory to all additional previous therapy. Five patients benefited from danazol and in two sustained normal platelet counts, for over 44 and 51 months, were observed. We conclude that danazol is useful for long t...

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Epidemiology of Idiopathic Thrombocytopenic Purpura in Children

Abstract Background Immune thrombocytopenic purpura (ITP) is a common autoimmune bleeding condition in children that is characterized by a decrease in the platelet count. The aims of this study were to define epidemiologic features of patients with primary ITP who were admitted to Mofid Children's Hospital, Tehran, Iran, in a 5-year period. Methods We retrospectively studied the records of ...

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Adult idiopathic thrombocytopenic purpura without the option of splenectomy.

In this part of Malaysia, consent of splenectomy is virtually unobtainable, so we studied the outcome of ITP without this treatment option. Thirty-two adult patients were seen, but 7 defaulted before therapy evaluation. Of the remaining 25, 17 achieved a complete remission with prednisolone, but in only 8 was this prolonged. Twelve patients, who failed to respond to prednisolone or who required...

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[Diagnosis and treatment of idiopathic thrombocytopenic purpura].

march 2012  25 © 2012 Human Kinetics IJATT 17(2), pp. 25-28 Idiopathic thrombocytopenic purpura (ITP) is a syndrome characterized by a low platelet count in the peripheral blood that is not related to marrow failure.1 ITP is a relatively common syndrome of unknown origin that is increasingly recognized. Approximately 66 adults and 50 children per 1,000,000 are diagnosed with ITP annually.2 The...

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About treatment of idiopathic thrombocytopenic purpura (ITP).

Their treatment results with megadose methylprednisolone (MDMP) support fairly closely our complete remission results, though theirs was a retrospective evaluation. In our prospective, comparative study, antiplatelet antibodies were also determined3. Their 80% complete remission rate (mistakenly written as 66% in the text) with MDMP administration was much better than other therapeutic approach...

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ژورنال

عنوان ژورنال: Nihon Toseki Igakkai Zasshi

سال: 2017

ISSN: 1340-3451,1883-082X

DOI: 10.4009/jsdt.50.635